He has starred as the lead in the films Johnson Family Vacation and Code Name: The Cleaner. His other films include First Reformed, Why Him?, A Haunted House 1 & 2, Larry Crowne, Cadillac Records, The Honeymooners (2005), Be Cool, Man of the House, A Series of Unfortunate Events, Intolerable Cruelty, Dr. Dolittle 2, and Big Momma's House. He has also done voice work for Ice Age, the Madagascar film series, Charlotte's Web (2006), Planes, and Planes: Fire & Rescue.
He hosted BET's ComicView during the 1993–1994 season and Def Comedy Jam in 1995 as well as the 12th season of the daytime version of Who Wants to Be a Millionaire in 2013–14.
In 2019, he received a star on the Hollywood Walk of Fame.